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These findings demonstrate a key role of Phe544 in the binding of the benzopyran IRAP inhibitors and for optimal positioning of enzymesubstrates during catalysis.
2
Further, relations between ALOX5 and disease outcomes may be enhanced or attenuated depending on the bioavailability of 5-lipoxygenase enzymesubstrates.
Solid (usually planar) substance onto which a layer of another substance is applied, and to which that second substance adheres; (in solid-state electronics) thin slice of material.